A ratiometric fluorescent probe for detection of exogenous mitochondrial SO2 based on a FRET mechanism |
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| Authors: | Zhiyang Xu Zhen Chen Aikun Liu Ruixue Ji Xiaoqun Cao Yanqing Ge |
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| Institution: | School of Chemistry and Pharmaceutical Engineering, Taishan Medical University, Tai''an 271000 PR China, +86-538-6229741 |
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| Abstract: | A novel imidazo1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO2 was designed and synthesized. The probe is based on a fluorescence resonance energy transfer (FRET) mechanism. It exhibits high selectivity and sensitivity towards SO32− with a fast response time (3 min) and detection limit of 0.13 μM. Further, it showed low cytotoxicity and was successfully applied to image exogenous mitochondrial SO2 in cells.A novel imidazo1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO2 was designed and synthesized. |
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