| 5-氟尿嘧啶-N-琥珀酰壳聚糖纳米粒冻干粉针制备 |
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| 引用本文： | 颜承云,谷继伟,黄展,于莲,苏瑾,孙维彤,陈大为. 5-氟尿嘧啶-N-琥珀酰壳聚糖纳米粒冻干粉针制备[J]. 黑龙江医药科学, 2011, 34(2): 19-20 |
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| 作者姓名： | 颜承云 谷继伟 黄展 于莲 苏瑾 孙维彤 陈大为 |
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| 作者单位： | 1. 佳木斯大学药学院,黑龙江,佳木斯,154007
2. 沈阳药科大学药学院,辽宁,沈阳,110016 |
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| 基金项目： | 黑龙江省教育厅重点项目 |
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| 摘 要： | 目的:考察5-氟尿嘧啶-N-琥珀酰壳聚糖纳米粒(5-FU-Suc-Chi/NPs)稳定性,制备纳米粒冻干粉针.方法:采用乳化溶剂挥发法制备5-FU-Suc-Chi/NPs;考察纳米粒溶液稳定性;优化纳米粒冻干粉针处方.结果:选定12%的甘露醇为5-FU-Suc-Chi/NPs的支架剂,制备纳米粒冻干粉.结论:5-FU-...
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| 关 键 词： | N-琥珀酰壳聚糖 纳米粒 稳定性 冻干粉针 |
Preparation of 5-fluorouracil loaded N-Succinyl-Chitosan (Suc-Chi) nanoparticles freeze-dry powder |
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| YAN Cheng-yun,GU Ji-wei,HUANG Zhan,YU Lian,SU Jin,SUN Wei-tong,CHEN Da-wei. Preparation of 5-fluorouracil loaded N-Succinyl-Chitosan (Suc-Chi) nanoparticles freeze-dry powder[J]. Heilongjiang Medicine and Pharmacy, 2011, 34(2): 19-20 |
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| Authors: | YAN Cheng-yun GU Ji-wei HUANG Zhan YU Lian SU Jin SUN Wei-tong CHEN Da-wei |
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| Affiliation: | YAN Cheng-yun1,GU Ji-wei1,HUANG Zhan1,YU Lian1,SU Jin1,SUN Wei-tong1,CHEN Da-wei2(1.College of Pharmacy,Jiamusi of University,Jiamusi 154007,China,2.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | Objective:To investigate the stability of 5-fluorouracil loaded N-Succinyl-chitosan nanoparticles(5-FU-Suc-Chi/NPs) and prepare 5-FU-Suc-Chi/NPs freeze-dry powder.Methods:5-FU-Suc-Chi/NPs were prepared by an emulsification solvent diffusion method,and the formulation of 5-FU-Suc-Chi/NPs freeze-dry powder was optimized by using glucose and lactose mannitol as supporting agents.Results:The idea formulation of 5-FU-Suc-Chi/NPs freeze-dry powder was obtained according to the results.Conclusion:5-FU-Suc-Chi/NPs ... |
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| Keywords: | N-Succinyl-chitosan nanoparticles stability freeze-dry powder |
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