神经元特异性烯醇化酶对Creutzfeldt-Jakob病的早期诊断价值

目的探讨脑脊液及血清神经元特异性烯醇化酶（NSE）对Creutzfeldt-Jakob病（CJD）的诊断意义。方法利用免疫组织化学方法定量检测脑脊液及血清NSE蛋白含量。检测了36例患者，其中clD组14例、其他痴呆组（OD）10例，非痴呆组（ND）12例。结果CJD组与OD组、ND组相比，其脑脊液及血清含量明显增高。其灵敏度分别为78．6％、73．3％，特异度分别为77．3％、72．7％。结论NSE检测可以用于CJD早期诊断，但血清NSE与CSF中NSE相比对于诊断sCJD的敏感性及特异性均下降。

Diagnosis value of the neuron-specific enolase in cerebrospinal fluid and serum in the early stage Creutzfeldt-Jakob disease

Objective] To inquire the diagnosis value of neuron-specific enolase in cerebrospinal fluid and serum in the early stage sporadic Creutzfeldt-Jakob disease. Methods] We analysised cerebrospinal fluid (CSF) and serum samples of 36 patients by ELISA. 14 of them are CJD, 10 of them are other dementia diseases(OD), the others are non dementia diseases(ND). Results] Compared CJD with OD and ND, it is significantly higher than two control groups. Sensitivity for diagnosis of CJD is 78.6%, 73.3% in CSF and seru...