青年抑郁症患者胼胝体MR扩散张量成像研究

目的 研究青年抑郁症患者胼胝体可能存在的细微结构异常。资料与方法 对54例青年抑郁症患者（抑郁症组）和38名年龄和性别匹配的正常志愿者（对照组）进行扩散张量成像（DTI）检查，测量胼胝体膝部、体部和压部的表观扩散系数（ADC）值和各向异性分数（FA），并对两组进行对比分析。结果 抑郁症组患者胼胝体膝部和体部的ADC值明显高于正常对照组，FA值明显低于对照组，P值均〈0．01；胼胝体压部的ADC值和FA值在两组间差异无统计学意义（P〉0．05）。抑郁症组内ADC、FA值的性别差异无统计学意义（P〉0．05）。结论 青年抑郁症患者胼胝体膝部和体部白质纤维束可能存在细微结构的改变。

Diffusion Tensor Imaging Study of Corpus Callosum in Youth Major Depression

Objective To investigate the microstructural abnormalities of the corpus callosum in youth major depression.Materials and Methods 54 patients with major depression and 38 subjects similar in age and gender to the patients as controls were performed diffusion tensor imaging (DTI) scanning. The apparent diffusion coefficient (ADC) and fractional antisotropys (FA) were measured from regions of interest in the genu(anterior), body and splenium(posterior) of corpus callosum, and the values of ADC and FA were analyzed between two groups.Results The values of ADC were significantly increased and FA significantly reduced in the genu and body of corpus callosum (P<0.01), the values of ADC and FA were not significantly difference in the splenium of the corpus callosum in the youth major depression group compared with the control group (P>0.05). There were no significant sex differences in the DTI measures in the youth major depression group (P>0.05).Conclusion There may be disruption of regional white matter tracts in the genu and body of the corpus callosum in patients with youth major depression.