善宁对大鼠肝缺血再灌注模型的保护作用

目的　评估善宁是否对大鼠肝缺血再灌注模型有保护作用.方法　我们选用30只成年SD大鼠随机分为3组，第1组给予假手术，第2组首先将肝右叶给予90min的热缺血，然后在恢复血流的同时进行肝中叶和肝左叶的肝切除（大约切除80%肝组织），第3组与第2组的手术操作完全相同，但在剖腹术到术后24h这段时间内用善宁（0.5μg/次/6h）皮下注射.而第1组、第2组都是用生理盐水处理大鼠.结果　经善宁处理的大鼠的生存率由0（第2组）提高至60%（第3组）（P<0.05），而且血胆红素降低［（7.1±1.7)mg

Effect of octreotide in rat hepatic ischemic reperfusion

AIM To evaluate effect of octreotide in rat hepatic ischemicreperfusion injury. METHODS Thirty adult male SD rats were randomly separated into three groups. The rats in group 1 underwent sham operations, and those in group 2 underwent a 90-minute-period of ischemia of the right lateral lobe. The rats in group 3 were given the same treatment as group 2 rats except that 0.5 μg of octreotide acetate subcutaneously every 6 h from 24 h before hepatic resection until sacrifice, group 1 and group 2 received saline solution instead of octreotide as a control. RESULTS Octreotide improved the animals'survival rates from 0 (group 2) to 60% (group 3) (P<0.05) and decreased bilirubin levels [(7.1±1.7) mg.L-1 (group 3) vs (31±0.4) mg.L-1 (group 2), P<0.05]. CONCLUSION Octreotide could be used to treat ischemic reperfusion injury.