| 环氧合酶-2对胃癌血管内皮生长因子及血管形成的影响 |
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| 引用本文： | 李建英,于皆平,冉宗学,罗和生,田耕.环氧合酶-2对胃癌血管内皮生长因子及血管形成的影响[J].肿瘤防治研究,2002,29(2):107-109. |
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| 作者姓名： | 李建英 于皆平 冉宗学 罗和生 田耕 |
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| 作者单位： | 430060,武汉大学人民医院消化内科 |
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| 摘 要： | 目的 探讨环氧合酶 2 (COX 2 )对胃癌血管内皮生长因子 (VEGF)的表达及血管生成的影响。方法 应用免疫组织化学技术检测胃癌组织中COX 2 ,VEGF表达和微血管密度 (MVD)。结果 COX 2在62 .2 %胃癌组织中表达增高 ,COX 2表达与VEGF表达显著相关 (γS=0 .5 85 ,P <0 .0 1 ) ,且COX 2和VEGF均阳性的胃癌组织MVD(64.0± 2 5 .4)亦明显高于两者均阴性者 (3 0 .7± 1 1 .5 ) (P <0 .0 1 )。结论 胃癌组织中存在COX 2的高表达 ,COX 2通过增加VEGF表达而促进肿瘤血管形成
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| 关 键 词： | 胃癌 COX-2 血管内皮生长因子 新生血管 |
| 文章编号： | 1000-8578(2002)02-0107-03 |
| 收稿时间： | 2001-10-12 |
| 修稿时间： | 2001年10月12 |
The effects of COX-2 expression on vascular endothelial growth factor and angiogenesis in gastric carcinoma |
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| LI Jian\|ying,YU Jie\|ping,RAN Zong\|xue,et al People's Hospital of Wuhan University,Wuhan ,China.The effects of COX-2 expression on vascular endothelial growth factor and angiogenesis in gastric carcinoma[J].Cancer Research on Prevention and Treatment,2002,29(2):107-109. |
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| Authors: | LI Jian\|ying YU Jie\|ping RAN Zong\|xue People's Hospital of Wuhan University Wuhan China |
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| Institution: | LI Jian\|ying,YU Jie\|ping,RAN Zong\|xue,et al People's Hospital of Wuhan University,Wuhan 430060,China |
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| Abstract: | Objective To investigate the effects of COX\|2 expression on vascular endothelial growth factor (VEGF) and angiogenesis in gastric carcinoma.Methods The expression of COX\|2, VEGF and microvascular density (MVD) was examined by immunohistochemical staining.Results COX\|2 expression was detected in 62.2% of gastric carcinoma;The expression of COX\|2 was significantly correlated with VEGF ( P <0.01);Increased expression of COX\|2 and VEGF was significantly correlated with an increase in MVD ( P <0.01).Conclusion COX\|2 overexpression was found in gastric carcinoma, COX\|2 may stimulate angiogenesis through VEGF upregulation. |
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| Keywords: | Gastric neoplasms COX\|2 VEGF Neovasculature |
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