大肠粘液腺癌107例临床分析

目的：探讨大肠粘液腺癌的临床病理特性及其综合治疗方面应该注意的问题。方法：回顾性分析107例大肠粘液腺癌临床和病理资料。结果：（1）与非粘液腺癌相比，大肠粘液腺癌好发于青年人（年龄＜45岁）；（2）粘液与非粘液腺癌皆好发于直肠，但粘液腺癌更多发于升结肠；（3）易向周围脏器组织浸润生长；（4）易发性远处淋巴结转移；（5）根治性手术切除率低；（6）术后复发率高，预后较差。结论：大肠粘液腺癌是一类预后较差的大肠癌，对大肠癌粘液癌应该采用较积极的综合治疗方式。

A clinical study on large intestinal mucoid adenocarcinoma:a report of 107 cases

Purpose\ The purpose of this report is to analyze the clinicopathologic features of colorectal mucinous adenocarcinoma(MC),which is generally believed to have a poor prognosis,in an attempt to assess ways in which the surgical outcome can be improved.Methods\ Clinicopathologic features of 107 patients with MC(11 3%),from among 947 patients with primary colorectal cancers,were compared with those of 840 patients with nonmucinous(non MC)adenocarcinoma.Results\ MC is more likely to invade the adjacent viscera and show more extensive lymph node involvement beyond the pericolonic region than non MC.Conclusion\ Based on these findings,a more aggressive attitude toward surgical intervention is recommended,including extensive lymph node dissection and the resection of adjacent organs that seems to be affected microscopically,to improve the surgical outcome of this clinical entity.