涎腺肿瘤组织中P185蛋白的表达

目的 :探讨涎腺肿瘤组织P185蛋白的表达及其与肿瘤生物学特性的关系。方法 :采用免疫组化SP法检测了 2 0例多形性腺瘤 (PA) ,12例腺淋巴瘤 (AL) ,19例恶性多形性腺瘤 (MPA)和 2 5例腺样囊性癌 (ACC)中neu基因的表达产物P185蛋白。结果 :PA组织中P185蛋白的阳性率为 10 .0 % (2 / 2 0 )。MPA组织中的阳性率为 5 7.9% (11/19) ,2组比较 ,差异有显著性 (P <0 .0 5 ) ;有淋巴结转移的恶性涎腺肿瘤中P185的阳性率为 10 0 % ,无淋巴结转移的阳性率为 48.6 % ,2组比较 ,差异有显著性 (P <0 .0 5 )。结论 :neu基因的表达产物P185蛋白在PA恶变过程中起着一定作用 ;P185蛋白检测可作为判断涎腺恶性肿瘤有无淋巴结转移的参考指标 ,为临床外科选择术式提供参考依据。

The expression of P185 protein in salivary gland tumors

Aim: To study the relationship between the expression of P185 protein in salivary gland tumor and the tumor biologic characteristics.Methods:Twenty cases of pleomorphic adenoma(PA),12 cases of adenolymphoma,19 cases of malignant pleomorphic adenoma(MPA) and 25 cases of adenoid cystadenoma carcinoma were examined to detect the neu gene product P185 protein by immunohistochemical SP method.Results:The positivity rate of P185 in MPA(57.9%) was significantly higher than that in PA(10.0%)( P <0.05); The positivity rate of P185 in malignant salivary gland tumors with lymph node metastasis (100%)was significantly higher than that without(48.6%)( P <0.05).Conclusion:P185 protein plays an important role in pleomorphic adenoma carcinogenesis;detection of P185 has the value of judging whether lymph node metastasis is present and providing scientific basis for selecting the operation pattern.