Changes in extracellular pH during electrical stimulation of isolated rat vagus nerve |
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| Authors: | W Endres P Grafe H Bostock G ten Bruggencate |
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| Affiliation: | 1. Department of Physiology and Pharmacology, University of Georgia, Athens, Georgia;2. Section on Drug Design and Synthesis, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, Bethesda, MD, USA;3. Optogenetic and Transgenic Technology Core, National Institute on Drug Abuse, Baltimore, MD, USA;4. Center for Social and Affective Neuroscience, Linkoping University, Linkoping, Sweden |
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| Abstract: | Double-barrelled pH-sensitive micro-electrodes were used to record changes of extracellular pH during repetitive stimulation of isolated rat vagus nerves. It was found that a small initial alkaline shift was followed by a prolonged acidification. The acidification was correlated in time with the poststimulus undershoot of the extracellular K+ activity and with the recovery phase of the nerve conduction velocity. In the presence of ouabain, the acid component of the pH change was completely abolished (indicating a metabolic origin), whereas the alkaline component remained unaltered. These pH changes were too small to make a significant contribution to the activity-related changes in conduction velocity of the vagal C-fibres. |
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