支气管哮喘患儿血清ECP和IgE检测临床意义

目的探讨血清嗜酸粒细胞阳离子蛋白(ECP)和免疫球蛋白IgE在哮喘患儿中的临床意义。方法对60例患儿和20例健康儿血清进行了ECP及IgE检测。结果哮喘发作期ECP水平显著高于稳定期、缓解期及健康对照;IgE发作期高于缓解期和健康儿,但缓解期与稳定期无显著差异(P>0.05)。此外,哮喘患儿血清ECP、IgE间无明显相关(P>0.05)。结论血清ECP水平能更准确反映嗜酸粒细胞活化状态和气道炎症变化,是诊断、判断病情及指导抗炎治疗的可靠指标。

Clinical Significance of Serum ECP and IgE in Children with Asthma

Objective To explore the clinical significance of serum eosinophil cationic protein(ECP) AND immunoglobuline E(IgE) in children with asthma.Methods ECP and IgE in serum of children with asthma were examined by the immuno-CAP system and ELISA respectively.In the meanwhile,20 healthy children were also detected as control.Results The concentration of ECP of asthmatic children in paroxysmal phase was obviously higher than that in stable and alleviated phase and the control group.The concentration of IgE of asthmatic children in paroxysmal phase was also significantly higher than that in alleviated phase and the control group but had no difference with that in stable phase(P>0.05).Conclusions These results suggest that the level of serum ECP can reflect the inflammation in the bronchial tube and the activated state of eosincyte more sensitively than IgE.