奥曲肽治疗肝硬化门静脉高压合并食管下段胃底静脉曲张首次破裂出血近期疗效观察

目的观察奥曲肽治疗肝硬化门静脉高压合并食管下段胃底静脉曲张首次破裂出血近期疗效及其不良反应。方法将50例肝硬化门静脉高压合并食管下段胃底静脉曲张首次破裂出血病人随机分为两组,对照组30例,奥曲肽治疗组20例,对照组在基础治疗(制酸、护肝、降低门静脉压、补液等)上加垂体后叶素治疗;治疗组在基础治疗上加奥曲肽治疗。同时观察两组止血情况及不良反应。结果治疗组有效率82.4%,对照组有效率61.2%,两组比较有差异统计学意义(P<0.05),且奥曲肽组不良反应少,患者耐受性好。结论奥曲肽治疗肝硬化门静脉高压合并食管下段胃底静脉曲张首次破裂出血近期疗效好,不良反应少,值得临床推广使用。

The recent curative effect of sandostatin on the first rupture of veins caused by high pressure of portal vein due to hepatocirrhosis and varicosity at the lower sect of oesophagus and the fundus of stomach

Objective This is aimed to look into the recent curative effect and side-effect of sandostatin on high pressure of portal vein caused by hepatocirrhosis and on the first rupture of veins by varicosity at the lower sect of oesophagus and the fundus of stomach.Methods Fifty patients with hepatocirrhosis and on the first rupture of veins by varicosity at the lower sect of oesophagus and the fundus of stomach were randomly divided into two groups namely, the control group (30), and treatment group (20). The patients in control group were treated with basic means (such as acid-ridding, liver-protecting, pressure-lowering of portal vein, fluid-supplying) and then with posterior pituitrin, and the patients in treatment group were treated with basic means and then with sandostatin. The effect of hemostasis and side-effects in the two groups were examined.Results It was found that the availability of the treatment group was 82.4%, and that of control group 61.2%, with the former having a significantly statistical advantage(P<0.05), moreover, with less side-effect and good reception.Conclusion It is concluded that sandostatin has a good curative effect but little side-effect on the first rupture caused by high pressure of portal vein due to hepatocirrhosis and varicosity at the lower sect of oesophagus and the fundus of stomach, and can be applied clinically.