血竭素的合成

本文报道了在以间苯三酚为原料合成血竭素的过程中,改进了中间体2,4,6-三羟基苯甲酸及2,6-二羟基-4-甲氧基-3-甲酰基-5-甲基苯甲酸甲酯的操作方法。以间苯三酚制备2,4,6-三羟基苯甲酸,收率为92%,较文献值提高约37%。以2,6-二羟基-4-甲氧基-3-甲基苯甲酸甲酯制备2,6-二羟基-4-甲氧基-3-甲酰基-5-甲基苯甲酸甲酯时,改变了氰化锌的用量,并去掉毒性极大的氢氰酸,收率为66.7%(文献收率64.6%)。

THE SYNTHESIS OF DRACORHODIN

In this paper it is reported that Dracorhodin was synthesized by using phloroglucinol asstarting material and the procedure was improved for preparing intermediates, 2, 4, 6-Trihy-droxybenzoic acid and methyl 2, 6-dihydroxy-4-methoxy-3-formyl-5-methylbenzoate. 2,4, 6-Trihydroxy benzoic acid was prepared by using phloroglucinol. The yield was 92%, about 37%higher than what the literature had reported. Methyl-2, 6-dihydroxy-4-methoxy-3-formyl-5-methylbenzoate was prepared by using methyl-2, 6-dihydroxy-4-methoxy-3-methylbenzoate astsarting material, so that extremely toxic Hydrogen cyanide was discarded and the amount ofzine cyanide was changed. The yield was 66.7% (The yield in the literature is 64.6%).