| Proteomics in Discovery of Hepatocellular Carcinoma Biomarkers |
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| 作者姓名： | 吴诚 李松涛 刘丽杰 王占锋 卢军华 刘保海 廖萍 王文静 朱樑 |
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| 作者单位： | [1]Department of Gastroenterology, the Second Affiliated Hospital [2]The First Out-Patient Clinic, the General Logistics Department of the PLA [3]Department of Statistics and Finance, China Science ＆ Technology University [4]Department of Surgery, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200043 [5]The Second Military Medical University, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200043 [6]Department of Public Health ＆ Molecular Biology, Shanghai Municipal Center for Disease Control and Prevention |
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| 基金项目： | This work was supported by a grant from the Technologies R ＆ D Program of Shanghai （No. 011209014）. |
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| 摘 要： | Objective： To discover new proteomic biomarkers of hepatocellular carcinoma. Methods： Surface enhanced laser desorption/ionization time-of-flight （SELDI-TOF） mass spectrometry was used to discover biomarkers for differentiating hepatocellular carcinoma and chronic liver disease. A population of 50 patients with hepatocellular carcinoma and 33 patients with chronic liver disease was studied. Results： Twelve proteomic biomarkers of hepatocellular carcinoma were detected in this study. Three proteomic biomarkers were highly expressed in hepatocellular carcinoma and nine proteomic biomarkers were highly expressed in chronic liver disease. The most valuable proteomic biomarker with m/z=11498 had no similar diagnostic value as α-fetoprotein. Conclusion： Some of the twelve proteomic biomarkers may become new biomarkers of hepatocellular carcinoma.
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| 关 键 词： | 肝细胞癌 肿瘤标记物 治疗 临床分析 |
| 文章编号： | 1000-9604（2007）03-0159-06 |
| 收稿时间： | 9 May 2007 |
| 修稿时间： | 2007-05-09 |
Proteomics in discovery of hepatocellular carcinoma biomarkers |
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| Wu Cheng,Li Song-tao,Liu Li-jie,Wang Zhan-feng,Lu Jun-hua,Liu Bao-hai,Liao Ping,Wang Wen-jing,Zhu Liang.Proteomics in Discovery of Hepatocellular Carcinoma Biomarkers[J].Chinese Journal of Cancer Research,2007,19(3):159-164. |
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| Authors: | Wu Cheng Li Song-tao Liu Li-jie Wang Zhan-feng Lu Jun-hua Liu Bao-hai Liao Ping Wang Wen-jing Zhu Liang |
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| Institution: | (1) Department of Gastroenterology, the Second Affiliated Hospital, China;(2) Department of Surgery, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai, 200043, China;(3) the General Logistics Department of the PLA, The First Out-Patient Clinic, China;(4) Department of Statistics and Finance, China Science & Technology University, China;(5) The Second Military Medical University, China;(6) Department of Public Health & Molecular Biology, Shanghai Municipal Center for Disease Control and Prevention, China |
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| Abstract: | Objective To discover new proteomic biomarkers of hepatocellular carcinoma.
Methods Surface enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry was used to discover biomarkers
for differentiating hepatocellular carcinoma and chronic liver disease. A population of 50 patients with hepatocellular carcinoma
and 33 patients with chronic liver disease was studied.
Results Twelve proteomic biomarkers of hepatocellular carcinoma were detected in this study. Three proteomic biomarkers were highly
expressed in hepatocellular carcinoma and nine proteomic biomarkers were highly expressed in chronic liver disease. The most
valuable proteomic biomarker with m/z=11498 had no similar diagnostic value as α-fetoprotein.
Conclusion Some of the twelve proteomic biomarkers may become new biomarkers of hepatocellular carcinoma.
The first two authors contributed equally to this work. |
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| Keywords: | Proteomics Biomarker Hepatocellular carcinoma |
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