| Expression of SKP2 Protein in Non-small Cell Lung Carcinoma |
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| 作者姓名： | 杨春鹿 赵君 赵苏英 |
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| 作者单位： | Department of Thoracic Surgery the First Affiliated Hospital China Medical University，Department of Thoracic Surgery Shenyang Municipal Thoracic Hospital，The 7th Shenyang Municipal People Hospital，Shenyang 110001，Shenyang 110044，Shenyang 110003 |
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| 摘 要： | Objective: To study the expressive characteristics of SKP2 protein in non-small cell lung carcinoma and it is affection to NSCLC patients' prognosis. Methods: The expression of SKP2 protein was detected in 89 NSCLC, 5 benign lung neoplasmas, 5 normal bronchus and lung tissues by Tissue Chip and immunohistochemistry technology. Results: The positive rate of SKP2 protein staining was (23.52±13.57)% in NSCLC tissues, significantly higher than that in benign lung neoplasmas, normal brochus and lung tissues (2.91±1.27)% (P=0.0000<0.001). The expressive level of SKP2 protein in NSCLC tissues was closely related to cell differentiation (P1=0.000<0.001), but not to age, sex, smoking history,pathological type, site, size, lymph node metastasis and TNM stage (each P1>0.05). The survival analysis displayed that the NSCLC patients' 5 years survival rate was lower in positive expression group than that in negative expression group (P1=0.042/0.031<0.05; r=-0.186, P2=0.000<0.001). Conclusion: The positive expression of SKP2 protein may play an enhancement role in the occurrence and development of NSCLC. Moreover, it may be a bad indicator to NSCLC patients' prognosis.
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| 关 键 词： | 肺癌 组织切片 免疫疗法 临床 |
| 文章编号： | 1000-9604（2007）03-0195-06 |
| 收稿时间： | 9 October 2006 |
| 修稿时间： | 2006-10-09 |
Expression of SKP2 protein in non-small cell lung carcinoma |
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| Yang?Chun-lu,Zhao?Jun,Zhao?Su-ying.Expression of SKP2 Protein in Non-small Cell Lung Carcinoma[J].Chinese Journal of Cancer Research,2007,19(3):195-200. |
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| Authors: | Yang Chun-lu Zhao Jun Zhao Su-ying |
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| Institution: | 1.Department of Thoracic Surgery, the First Affiliated Hospital, China Medical University, Shenyang 110001; 2.Department of Thoracic Surgery, Shenyang Municipal Thoracic Hospital, Shenyang 110044; 3.The 7th Shenyang Municipal People Hospital, Shenyang 110003 |
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| Abstract: | Objective: To study the expressive characteristics of SKP2 protein in non-small cell lung carcinoma and it is affection to NSCLC patients' prognosis. Methods: The expression of SKP2 protein was detected in 89 NSCLC, 5 benign lung neoplasmas, 5 normal bronchus and lung tissues by Tissue Chip and immunohistochemistry technology.Results: The positive rate of SKP2 protein staining was (23.52±13.57)% in NSCLC tissues, significantly higher than that in benign lung neoplasmas, normal brochus and lung tissues (2.91±1.27)% (P=0.0000＜0.001). The expressive level of SKP2 protein in NSCLC tissues was closely related to cell differentiation (P1=0.000＜0.001),but not to age, sex, smoking history, pathological type, site, size, lymph node metastasis and TNM stage (each P1＞0.05). The survival analysis displayed that the NSCLC patients' 5 years survival rate was lower in positive expression group than that in negative expression group (P1=0.042/0.031＜0.05; r=-0.186, P2=0.000＜0.001).Conclusion: The positive expression of SKP2 protein may play an enhancement role in the occurrence and development of NSCLC. Moreover, it may be a bad indicator to NSCLC patients' prognosis. |
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| Keywords: | NSCLC SKP2 protein Cell cycle Tissue Chip Immunohistochemistry |
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