首例氨曲南导致急性剥脱性皮炎和急性再生障碍性贫血同发

目的：首次报告氨曲南用药后1例83岁男性患者同时发生急性剥脱性皮炎和急性再生障碍性贫血，探讨其发病的可能易感因素，为临床安全用药提供依据。方法：仔细分析了患者急性剥脱性皮炎和急性再生障碍性贫血发病前后的用药、皮肤和血液各项指标的变化情况。对氨曲南的不良反应进行了文献复习。结果：氨曲南可以引起皮肤和造血系统的不良反应，但同时并发急性剥脱性皮炎和急性再生障碍性贫血实属罕见。高龄、用药前有血液系统异常可能是氨曲南发生严重不良反应的危险因素。结论：氨曲南用药应严格掌握适应症，对高龄或有造血异常的患者用药应该格外慎重。氨曲南用药过程中应密切注意皮肤和黏膜的改变并要定期监测血象。

Acute aplastic anemia and toxic epidermal necrolysis caused by sensitization to aztreonam: the first report

Objective:To first report a 83-year-old man presented with Acute aplastic anemia(AAA) and toxic epidermal necrolysis(TEN) after receiving injection of aztreonam.Methods:After thoroughly analyzed the drug regimen,blood test changes before and after AAA and TEN occurance,then review the literature related with the side effects of Azetreonam.Results:Azetreonam can cause side effects on skin and hematological system with a low incidence manner.Conclusion:Azetreonam should be used with a strict indication in the treatment of system infection,especialy in old patient or patient with hemalogical disorder.(Also),thoroughly skin obervation and blood test should be made regularly during the Azetreonam treatment.aztreonam;dermatitis,exfoliative;anemia,aplastic