利多卡因在全麻诱导中预防芬太尼诱发呛咳反应的临床观察

目的观察利多卡因在全麻诱导中能否抑制芬太尼诱发的呛咳反应。方法选择100例ASAI—II级全麻择期手术患者，随机分为利多卡因组和对照组，每组50例。组I为对照组，实验药物为生理盐水5ml，组Ⅱ为利多卡因1．5mg／kg，两组药物分别在全麻诱导中静脉给予芬太尼前1min时给予。观察芬太尼诱发呛咳的发生率及诱导期血流动力学的变化。结果两组呛咳的发生率分别为：组I26％，组II6％，组Ⅱ呛咳发生率明显降低（P〈0．05），但诱导前后血流动力学的变化一致。结论应用利多卡因在全麻诱导中能安全有效地预防芬太尼诱发的呛咳反应。

The inhibition effect of lidocaine on irritating cough caused by fentanyl in general anesthesia induction

Objective To evaluate the inhibition effect of lidocaine on irritating cough caused by fentanyl in general anesthesia induction. Method 100 ASA I-II patients undergoing operation randomly received treatment with 5 ml saline ( I group;n=50) or 1.5 mg/kg lidocaine ( II group;n=50) 1 minute before fentanyl was given, and the incidence of irritating cough and hemodynamic changes in patients were evaluated in anesthesia induction period. Result The occurrence of irritating cough in II group was significantly lower than that in I group (6% vs. 26%, P<0.05). and no difference was observed in hemodynamic changes between both group. Conclusion Lidocaine may present an effective way to prevent the occurrence of irritating cough caused by fentanyl in general anesthesia induction.