Improvement of schizophrenic symptoms and changes in plasma HVA concentrations, plasma anti-D2 and anti-5-HT2 receptor activities with clozapine |
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| Authors: | KAZUO YAMADA MD SHIGENOBU KANBA MD PHD WANG ZU-CHENG MD EIJI SUZUKI MD FANG YI-YU MD YAN HE-GIN MD MASASHI NIBUYA MD GOHEI YAGI MD PHD MASAHIRO ASAI MD PHD |
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| Affiliation: | Department of Neuropsychiatry, Keio University School of Medicine, Tokyo;Department ofNeuropsychiatry, Jiundou-Naika Hospital, Tokyo, Japan;Department of Psychiatry, Shanghai Second Medical College, Shanghai, China |
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| Abstract: | Abstract In order to investigate the biological mechanisms underlying the clinical efficacy of clozapine, 200 mg/day of clozapine was added to the drug regimens of 19 patients with chronic, anti-psychotic-resistant schixophrenia, and the plasma homovanillic acid (HVA), clozapine concentrations, anti-dopamine D2 and anti-serotonin 5-HT2 receptor activities were measured. After 28 days, six patients showed an improvement of more than 20% over baseline Brief Psychiatric Rating Scale (BPRS) scores. Mean plasma HVA concentrations and anti-D2 receptor activities did not change significantly in the entire group or in the six patients showing improvement. However, anti-5-HT2 receptor activities increased significantly in all 19 patients. Changes in BPRS scores did not correlate significantly with changes in plasma HVA or with changes in clozapine concentrations, or with anti-D2 and anti-5-HT2 receptor activities. |
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| Keywords: | anti-dopamine D2 activity anti-serotonin 5-HT2 activity Brief Psychiatric Rating Scale clozapine plasma homovanillic acid. |
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