High-grade ovarian cancer secreting effective exosomes in tumor angiogenesis |
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| Authors: | Huan Yi Jun Ye Xiao-Mei Yang Li-Wen Zhang Zhi-Gang Zhang Ya-Ping Chen |
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| Institution: | 1Fujian Maternity and Children Health Hospital Fujian Medical University Teaching Hospital, Fuzhou 350005, China;2The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China;3State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China |
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| Abstract: | Ovarian cancer, the most lethal gynecological cancer, related closely to tumor stage. High-grade ovarian cancer always results in a late diagnose and high recurrence, which reduce survival within five years. Until recently, curable therapy is still under research and anti-angiogenesis proves a promising way. Tumor-derived exosomes are essential in tumor migration and metastases such as angiogenesis is enhanced by exosomes. In our study, we have made comparison between high-grade and unlikely high-grade serous ovarian cancer cells on exosomal function of endothelial cells proliferation, migration and tube formation. Exosomes derived from high-grade ovarian cancer have a profound impact on angiogenesis with comparison to unlikely high-grade ovarian cancer. Proteomic profiles revealed some potential proteins involved in exosomal function of angiogenesis such as ATF2, MTA1, ROCK1/2 and so on. Therefore, exosomes plays an influential role in angiogenesis in ovarian serous cancer and also function more effectively in high-grade ovarian cancer cells. |
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| Keywords: | Ovarian cancerexosome angiogenesis proteomic profiles |
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