Wide-field in vivo oral OCT imaging |
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| Authors: | Anthony M. D. Lee Lucas Cahill Kelly Liu Calum MacAulay Catherine Poh Pierre Lane |
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| Affiliation: | 1Department of Integrative Oncology - Cancer Imaging Unit, British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada;2Faculty of Dentistry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada |
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| Abstract: | We have built a polarization-sensitive swept source Optical Coherence Tomography (OCT) instrument capable of wide-field in vivo imaging in the oral cavity. This instrument uses a hand-held side-looking fiber-optic rotary pullback catheter that can cover two dimensional tissue imaging fields approximately 2.5 mm wide by up to 90 mm length in a single image acquisition. The catheter spins at 100 Hz with pullback speeds up to 15 mm/s allowing imaging of areas up to 225 mm2 field-of-view in seconds. A catheter sheath and two optional catheter sheath holders have been designed to allow imaging at all locations within the oral cavity. Image quality of 2-dimensional image slices through the data can be greatly enhanced by averaging over the orthogonal dimension to reduce speckle. Initial in vivo imaging results reveal a wide-field view of features such as epithelial thickness and continuity of the basement membrane that may be useful in clinic for chair-side management of oral lesions.OCIS codes: (170.4500) Optical coherence tomography, (170.3890) Medical optics instrumentation, (170.4580) Optical diagnostics for medicine, (170.1610) Clinical applications, (170.1850) Dentistry, (170.4940) Otolaryngology |
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