MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y-LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD |
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Authors: | M J Morris P M Pilowsky J B Minson M J West J P Chalmers |
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Institution: | Department of Medicine and Centre for Neuroscience, Flinders Medical Centre, Adelaide, South Australia, Australia |
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Abstract: | Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline-containing neurons. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y-like immunoreactivity into the spinal subarachnoid space. These data provide evidence for a functional bulbospinal neuropeptide Y-containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla. |
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Keywords: | blood pressure bulbospinal neurons neuropeptide Y spinal cord perfusion ventrolateral medulla |
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