| 用标记分析法检测我国海南省登革2型病毒抗原性变化 |
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| 引用本文： | 司炳银,杨佩英,徐品芳,李瑞霞,陈文洲,阎国珍.用标记分析法检测我国海南省登革2型病毒抗原性变化[J].细胞与分子免疫学杂志,1990(1). |
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| 作者姓名： | 司炳银 杨佩英 徐品芳 李瑞霞 陈文洲 阎国珍 |
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| 作者单位： | 军事医学科学院微生物流行病研究所，军事医学科学院微生物流行病研究所，军事医学科学院微生物流行病研究所，军事医学科学院微生物流行病研究所，海南省卫生防疫站，军事医学科学院微生物流行病研究所 北京 100850，北京 100850，北京 100850，北京 100850，北京 100850 |
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| 摘 要： | 我们试用标记分析法,用3种单克隆抗体(黄病毒科特异性、登革病毒属特异性和登革病毒2型型特异性单克隆抗体)研究了我国海南省1985～1987年3年内流行的登革2型病毒8个流行株的抗原性变化,并与标准株新几内亚B株进行了比较。发现6株与标准株类似,2株显示出明显的差异。标记分析法为病毒抗原分析提供了一个简便、快速的方法,可用来监测一个地区病毒株群的变化及新株的传入。
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| 关 键 词： | 登革热病毒 抗原 病毒 标记分析 抗体 单克隆 |
Antigen Signature Analysis of Dengue-2 Viruses from Hainan,China |
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| Si Bingyin,Yang Peiying,Xu Pinfang,Li Ruixia,Chen Wenzhou and Yan Guozhen.Antigen Signature Analysis of Dengue-2 Viruses from Hainan,China[J].Journal of Cellular and Molecular Immunology,1990(1). |
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| Authors: | Si Bingyin Yang Peiying Xu Pinfang Li Ruixia Chen Wenzhou and Yan Guozhen |
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| Abstract: | Defining the extent of antigenic variation between dengue-2 viruses from Hainan province was tried, which had been isolated over a period of three years(1985-1987). The dengue-2 viruses were compared with the prototype New Guinea B strain and were subjected to antigen signature analysis. Eight strains of dengue-2 virus were analyzed by three monoclonal antibodies, flaviviridae, dengue-virus and dengue-2 type specific reactive epitopes, over a range of antigen concentration. Six out of eight of dengue-2 virus were shown to be antigenically homogeneous, and the remaining two strains, to be heterogeneous. Signature analysis provides a rapid and simple means to differentiate strains derived from different sources, thus permiting monitoring changes or introduction of new dengue virus populations in certain geographic region. |
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| Keywords: | dengue virus antigen viral signature analysis antibodies monoclonal |
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