| 癌钙调蛋白在炎症反应促视神经再生作用中的研究进展 |
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| 引用本文： | 马林昆,曹霞,罗生平. 癌钙调蛋白在炎症反应促视神经再生作用中的研究进展[J]. 国际眼科杂志, 2017, 17(7): 1268-1270. DOI: 10.3980/j.issn.1672-5123.2017.7.17 |
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| 作者姓名： | 马林昆 曹霞 罗生平 |
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| 作者单位： | 1. 昆明医科大学第二附属医院 眼科,中国云南省昆明市,654000;2. 昆明医科大学第二附属医院 中心实验室,中国云南省昆明市,654000 |
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| 基金项目： | 云南省中青年学术技术带头人后备人才培养项目(No.2015HB041); 云南省高校外科重大疾病诊治工程中心 |
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| 摘 要： | 癌钙调蛋白(oncomodulin,OM)作为钙结合蛋白的一种,逐渐为我们熟知.近年来有研究证实,OM源于活化的炎症细胞(中性粒细胞),是体内先天免疫系统和神经元之间一种有效的生长促进信号,通过炎症反应诱导的OM是受损视神经轴突再生的关键.OM的促视神经轴突再生作用逐渐成为研究的热点之一.本文就近年来OM作用机制和炎症诱导下OM与视神经再生关系方面的研究和进展做一综述.
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| 关 键 词： | 癌钙调蛋白 炎症反应 中性粒细胞 视神经再生 |
| 收稿时间： | 2017-01-17 |
| 修稿时间： | 2017-06-09 |
Role of inflammation in the relationship between OM and regeneration of optic nerves |
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| Lin-Kun M,Xia Cao and Sheng-Ping Luo. Role of inflammation in the relationship between OM and regeneration of optic nerves[J]. International Eye Science, 2017, 17(7): 1268-1270. DOI: 10.3980/j.issn.1672-5123.2017.7.17 |
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| Authors: | Lin-Kun M Xia Cao Sheng-Ping Luo |
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| Affiliation: | Department of Ophthalmology,the Second Affiliated Hospital of Kunming Medical University, Kunming 654000, Yunnan Province, China,Department of Central Laboratory, the Second Affiliated Hospital of Kunming Medical University, Kunming 654000, Yunnan Province, China and Department of Ophthalmology,the Second Affiliated Hospital of Kunming Medical University, Kunming 654000, Yunnan Province, China |
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| Abstract: | Oncomodulin(OM)is known by us progressively as a Calcium binding protein. Recently, OM has been found that it is secreted by inflammatory cells(neutrophilic granulocyte), and a signal which can promote cell growth between innate immunity and neurons, and a key to regenerate the damaged optical nerves by activating inflammation. The function of promoting the regeneration progress of axons has become a hot issue in recent years. This article summarized the mechanism of OM and the relationship between inflammation-induced OM and optic nerve regeneration research and progress were reviewed. |
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| Keywords: | oncomodulin inflammation neutrophils optic nerve regeneration |
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