血清同型半胱氨酸水平与冠心病的相关性探讨

目的：探讨血清同型半胱氨酸（Hcy）、叶酸及维生素（Vit)B12水平与冠心病（CHD）的相关性。方法：应用荧光微粒子发光法（测定Hcy及VitB12）及离子捕捉法（测定叶酸）检测CHD组（A组）、其它心血管疾病组（B组）和健康对照组（C组）各30例受检查血清Hcy、叶酸、VitB12水平。结果：A组血清Hcy含量明显高于B组（P＜0．01）及C组（P＜0．01）；A组血清叶酸含量明显低于B组（P＜0．01）及C组（P＜0．01）；A组血清VitB12含量明显低于B组（P＜0．05）及C组（P＜0．05）。结论：血清Hcy水平的升高与CHD可能有明显的关系。叶酸和VitB12水平的下降与Hcy水平的升高在CHD的发生中可能起着相似的作用。

The relationship between serum homocysteine level and coronary heart disease

Objective To determine the relation of serum homocysteine(Hcy),folic acid and vitamin B 12 with coronary heart disease(CHD).Methods Serum specific Hcy,folic acid and Vitamin B 12 were measured in 30 patients with CHD(group A) and 30 patients with cardiovascular disease(group B) and 30 heathy controls(group C).Results The concentration of serum Hcy in the group A was significantly higher than that of the group B(P<0.01) and the group C(P<0.01).The serum folic acid in the group A was much lower than that of the group B(P<0.01) and the group C(P<0.01).The serum vitamin B 12 in the group A was much lower than that of the group B(P<0.05) and the group C(P<0.05).Conclusion The Hcy level is associated with CHD.Hcy,vitamin B 12 and folic acid have similar effects in this respect.