果糖注射液对住院患者血糖水平影响的双盲平行对照试验

目的 比较果糖与葡萄糖静脉输注后对血糖水平的影响 ,评价其用于临床能量补充的有效性与安全性. 方法 采用随机、双盲平行对照试验 ,41例住院患者分为试验组和对照组两组 ,分别每天接受 50 g/L果糖或 50 g/L葡萄糖注射液 25 g,连续 3d,于给药前、给药结束时、给药后 2h测定血糖浓度 ,并同时于试验前和试验结束后检测肝、肾功能. 结果 20例住院患者静脉输注 50 g/L果糖注射液后即刻血糖水平平均为 (5.82± 1.54)mmol/L,明显低于 21例住院患者静脉输注 50 g/L葡萄糖注射液即刻平均血糖水平为 (7.61± 2.15)mmol/L(t=2.28,P< 0.05);输注后 2h血糖水平试验组平均 (5.51± 1.56)mmol/L,对照组平均为 (6.33± 2.38)mmol/L,两组比较差异无显著性意义 (P >0.05);给药前及给药后 2h自身前后血糖水平比较结果显示 ,试验组患者血糖水平差异无显著性意义 (P >0.05);对照组患者血糖水平差异有显著性意义 (t=2.84,P< 0.05);50 g/L 果糖注射液对肝、肾功能、血尿液等指标无影响. 结论 输注 50 g/L葡萄糖注射液后血糖水平波动明显小于 50 g/L葡萄糖注射液 ,50 g/L果糖注射液用于临床患者机体能量补充安全有效.

Effects of D-fructose infusion on blood glucose levels in hospitalized patients:a double blind parallel controlled clinical trial

AIM:To investigate the clinical effectiveness and reliability of D-fructose injection of vein for energy supply by comparing with glucose through their effects on blood glucose level of hospitalized patients. METHODS: A randomized double blind parallel controlled clinical trial was performed.A total of 41 hospitalized patients,who needed energy supply,were randomly divided into trial group(n=20) and control group(n=21). They received 50 g/L D-fructose or 50 g/L glucose 500 mL/L intraveneouly daily for 3 days.The blood glucose concentrations were estimated before and 0 hour and 2 hours after each administration.Liver and renal functions were also tested. RESULTS:Blood glucose level was (1.8± 1.5)mmol/L on everage soon after injecton of 50 g/L D-fructose,and it was obviously less than that of 21 patients (7.2± 2.2)mmol/L after injection of 50 g/L glucose.Two hours after injection,blood glucose levels in trial and control group were (5.5± 1.6)and (6.3± 2.4)mmol/L repectively.The difference between them had no statistical significance.Comparative results of blood glucose level before injection and 2 hours after injection showed that patients in trial group had no statistical significance;while patients in control group had. CONCLUSION: Blood glucose fluctuation after injecting 50 g/L D-fructose parenteral solution is obviously less than 50 g/L glucose does.5 g/L D-fructose was efficient and safe for energy supply in hospitalized patients.