Synthesis and analgesic activity of new 1,3,4-oxadiazoles and 1,2,4-triazoles |
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| Authors: | Ali Almasirad Abbas Shafiee Mohammad Abdollahi Amir Noeparast Nasir Shahrokhinejad Nasim Vousooghi Sayyed Abbas Tabatabai Reza Khorasani |
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| Affiliation: | (1) Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, 1941933111 Tehran, Iran;(2) Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, 14174 Tehran, Iran;(3) Department of Pharmacology and Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, 14174 Tehran, Iran;(4) Department of Pharmacology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;(5) Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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| Abstract: | A series of new 1,3,4-oxadiazoles and 1,2,4-triazoles were synthesized in order to obtain new compounds with potential analgesic activity. Compounds were evaluated for their analgesic activities by formalin-induced nociception test. Mefenamic acid (as the reference drug) did not show any activity in the early phase of the formalin test, while compounds 7b, 7c, 8c, and 9a significantly reduced the nociception in this phase. However in the late phase of formalin test all of the target compounds and mefenamic acid showed analgesic activity in comparison to control. |
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