Synthesis and cytotoxic activity of novel benzopyrano[3,2-c]chromene-6,8-dione derivatives |
| |
Authors: | Abbas Shafiee Radineh Motamedi Omidreza Firuzi Savis Meili Ahmad Reza Mehdipour Ramin Miri |
| |
Affiliation: | (1) Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;(2) Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14174, Iran;(3) Department of Chemistry, Payame Noor University, Delijan, Iran;(4) Medicinal & Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, P.O. Box 3288-71345, Shiraz, Iran; |
| |
Abstract: | 4-Hydroxycoumarins constitute the structural nucleus of many natural products, drugs, and pesticides. Promising biological properties in new families of synthetic coumarins were recently reported. Therefore, efficient synthesis of new benzopyrano[3,2-c]chromene-6,8-dione was undertaken and the structures of 15 compounds were confirmed by their IR, Mass, 1H-NMR, and C, H, N analysis. Then, the cytotoxic activities of these compounds were assessed on four different human cancer cell lines (Raji, HeLa, LS180, and MCF-7). The results showed that these compounds had weak-to-moderate antitumoral activities and their IC50 ranged from 49 to more than 100 μM. Among the compounds 9,10-dihydro-7-(3-methoxyphenyl)-7H,11H-benzopyrano[3,2-c]chromene-6,8-dione [4k] demonstrated the highest activity. Furthermore, conformational analysis revealed that ortho substituents were clearly different from meta and para substituents. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|