137株肠球菌的临床分布及耐药性分析

目的 了解肠球菌引起院内感染的临床分布及肠球菌对常用抗菌药的耐药状况,指导临床合理用药。方法 按《全国临床检验操作规程》及Sensititre Aris全自动细菌鉴定仪鉴定各临床标本分离的肠球菌,分别进行纸片扩散法药敏试验和β-内酰胺酶测试,并以WHONET软件对试验数据进行分析处理。结果137株肠球菌属中粪肠球菌占91.2％,屎肠球菌占7.3％,其他肠球菌占1.5％,产β-内酰胺酶的肠球菌占6.％,对万古霉素耐药率为2.9％,高浓度庆大霉素耐药率为76.6％,替考拉宁耐药率最低。肠球菌在各类感染性标本中的检出率以尿液最多,占42.3％。结论 肠球菌是造成医院感染的主要病原菌之一,以粪肠球菌多见。临床上以泌尿系统、呼吸系统感染为主;肠球菌存在严重耐药性,屎肠球菌耐药高于粪肠球菌;对不同肠球菌感染应采取不同治疗方案。

Analysis on Drug- tolerance and Clinical Distribution of 137 Strains of Enterococcus

Objective To learn the clinical distribution of hospital infection caused by enterococcus and drug-tolerance of enterococcus to commo Method National clinical operation rules and sensititre Aris toi- dentify enterococcus separated from clinical specimen paper distribution drug sensitive test andβ- lactamase test,and using WHONET software to analyze data.Results The feces enterococcus wsa 91.2% in 137 strains of enterococcus,and the enterococcus was 7.3%;enterococcus producing β-lactamase was 6.6%;the rate of drug-tolerance to vancomycin was 2.9%;the rate of drug-tolerance to high chroma gentamicin was 76.6%. The rate of enterococcus in urine spcimen was the highest among all kinds of infec-tion specimen,(42.3%). Conclusions Enterococcus was one of main bacteria that caused hospital infec-tion,and feces enterococcus was the primary. The infection of urinary system and respiratory system was pri-mary and the drug-tolerance of enterococcus was severe. We should use varied therapy project to cure differ-ent enterococcus infection.