| 下咽癌组织Th1/Th2类细胞因子的表达及意义 |
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| 引用本文： | 陈雪梅,许晓群,赵建东,朱莉,薛爱英,张大良.下咽癌组织Th1/Th2类细胞因子的表达及意义[J].临床耳鼻咽喉头颈外科杂志,2004,18(6):327-328. |
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| 作者姓名： | 陈雪梅 许晓群 赵建东 朱莉 薛爱英 张大良 |
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| 作者单位： | 1. 山东大学第二医院耳鼻咽喉科,济南,250033
2. 山东省医学科学院基础医学研究所 |
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| 摘 要： | 目的：检测下咽癌组织中辅助性T淋巴细胞(Th)1／Th2类细胞因子的表达，探讨其在下咽癌发生发展中的可能作用。方法：采用逆转录聚合酶链反应(RT—PCR)技术，检测5例正常人及20例下咽癌组织中Th1／Th2类细胞因子的基冈表达：结果：20例下咽癌组织中．主导Th2类细胞因子的白细胞介素(IL)-4和IL-10呈强势表达，而主导Th1类细胞因子的干扰素γ(IFN-γ)和IL-2基本不表达或表达较弱。结论：下咽癌组织Th2类细胞因子旱强势表达．可能是下咽癌患者免疫功能低下、促肿瘤生长的原因之一。
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| 关 键 词： | 下咽肿瘤 T淋巴细胞 辅助 细胞因子 基因表达 |
| 文章编号： | 1001-1781(2004)06-0327-02 |
| 修稿时间： | 2003年9月16日 |
The gene expression of Th1/Th2 cytokines and its role in hypopharyngeal carcinoma |
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| CHEN Xuemei,XU Xiaoqun,ZHAO Jiandong ZHU Li,XUE Aiying,ZHANG Daliang.The gene expression of Th1/Th2 cytokines and its role in hypopharyngeal carcinoma[J].Journal of Clinical Otorhinolaryngology,2004,18(6):327-328. |
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| Authors: | CHEN Xuemei XU Xiaoqun ZHAO Jiandong ZHU Li XUE Aiying ZHANG Daliang |
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| Institution: | Department of Otolaryngology, the Second Affiliated Hospital of Shandong University, Jinan, 250033, China. |
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| Abstract: | Objective:To observe the mRNA expression of Th1/Th2 cytokines in hypopharyngeal neoplasms and to explore the pathogenesis of it.Method:The gene expression of Th1/Th2 cytokines in patients with hypopharyngeal neoplasms was detected by RT PCR.Result:The cytokines expression of Th2 was significantly stronger than Th1 in tissue of hypopharyngeal carcinoma.Conclusion:The dominant expression of Th2 cytokines in hypopharyngeal neoplasms may inhibit the human immunity and enhance the growth and metastasis of hypopharyngeal carcinoma. |
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| Keywords: | Hypopharyngeal neoplasms T lymphocytes helper Cytokine Gene expression |
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