Intravenous human immunoglobulin treatment for neonatal alloimmune thrombocytopenia due to anti-HPA-5b with severe previous history] |
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| Authors: | P Moncharmont M Vignal Y Merieux D Rigal |
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| Affiliation: | 1. Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland;2. Department of Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland;3. Department of Nephrology, Independent Public State Integrated Hospital, Szczecin, Poland;4. Department of Epidemiology and Management, Faculty of Health Sciences, Pomeranian Medical Univeristy, Szczecin, Poland;1. CIC nanoGUNE Consolider, Tolosa Hiribidea 20018 Donostia/San Sebastian, Spain;2. Biosurfaces Unit, CIC biomaGUNE, Miramon Pasealekua 182, 20009 Donostia/San Sebastian, Spain;3. Biofunctional Nanomaterials Unit, CIC biomaGUNE, Miramon Pasealekua 182, 20009 Donostia/San Sebastian, Spain;4. CIBER-BBN, Miramon Pasealekua 182, 20009 Donostia/San Sebastian, Spain;5. Charité-Universitätsmedizin Berlin, Institute of Transfusion Medicine, Charitéplatz 1, 10117 Berlin, Germany;6. Department of Medical Physics, Biophysics and Radiology, Medical Faculty, Trakia University,, ul. Armeiska 11, 6000 Stara Zagora, Bulgaria;7. Institute for Biophysics, Department of Nanobiotechnology, University of Natural Resources and Life Sciences Vienna (BOKU), Muthgasse 11, A-1190 Vienna, Austria;1. Research and Development Division, Japan Blood Products Organization, Hyogo, Japan;2. Bioprocess Division, Asahi Kasei Medical, Tokyo, Japan;3. Manufacturing Technology Association of Biologics, Tokyo, Japan |
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| Abstract: | Fetal and neonatal alloimmune thrombocytopenia due to mothers' anti-HPA-5b alloimmunization has generally a milder clinical presentation compared to anti-HPA-1a alloimmunization. Nevertheless, a case with infant's death probably due to intracranial haemorrhage has been reported. However, if platelet-specific alloimmunized mothers with prior fetal or neonate injury receive intravenous immunoglobulins during pregnancy, thrombocytopenia in heterozygous fetus and neonate may be prevented. Here are reported 2 cases of anti-HPA-5b fetal-maternal alloimmunization, one with prior fetal death, the other with prior severe fetal intracranial haemorrhage, which were successfully treated with intraveinous immunoglobulins alone during a second pregnancy with HPA-5b incompatibility. |
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