New HLA-B alleles identified and sequences extended in potential bone marrow donors: B*5804, B*4418, B*1558, and B*4805 |
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Authors: | Williams T M Wu J Bassinger S Feldman D Birkos S Kearns J Kamoun M |
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Institution: | Department of Pathology, University of New Mexico, Albuquerque 87131-5051, USA. twilliams@salud.unm.edu |
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Abstract: | Nucleic acid-based methods for allele identification have revealed more than 470 polymorphic variants at the HLA-B locus. Screening of potential bone marrow donors with sequence specific primer polymerase chain reactions and sequence specific oligonucleotide probe hybridization assays revealed apparent variants within the B*58, *44, *15, and *48 allele groups. DNA sequencing of cloned DNA identified the new alleles B*5804, B*4418, and B*1558 within these groups and observed new sequence information for the previously reported allele B*4805. These findings further extend our knowledge of the substantial genetic variation present at the HLA-B locus within human populations. |
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Keywords: | bone marrow transplantation DNA sequencing HLA-B |
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