L-精氨酸对肝缺血再灌注损伤的保护作用

目的 :研究L 精氨酸在肝缺血再灌注损伤中的作用。方法 :将 12只杂种狗随机分成对照组 (生理盐水组 )和实验组 (L 精氨酸组 ) ,每组 6只建立肝缺血再灌注实验模型 ,肝缺血时间为 45min ,于再灌注后 30min、1h、2h分别抽血测血清丙氨酸氨基转移酶 (ALT)、一氧化氮 (NO)、丙二醛 (MDA)含量。结果 :再灌注各时间点实验组ALT含量均明显低于对照组 ,而再灌注 1、2h ,实验组NO含量明显高于对照组 ,实验组MDA含量明显低于对照组。结论 :L 精氨酸在肝缺血再灌注损伤中起一定保护作用。

Protective effect of L-arginine in hepatic ischemia-reperfusion injury

Objective:To investigate the effect of L-arginine in hepatic ischemia-reperfusion injury. Methods:Twelve hybrid dogs were randomly divided into two groups:the control group (saline) and the experimental group (L-arginine) group. The hepatic ischemia-reperfusion models were established in each group ( n =6). The time of hepatic ischemia was 45 minutes. Serum alanine aminotransferase(ALT), nitric oxide(NO) and malonydialdehyde(MDA) content were measured at 30 min, 1 h and 2 h, respectively, after the reperfusion. Results:ALT content of the experimental group was significantly lower than that of the control group at 30 min, 1 h and 2 h; NO content was significantly higher than that of the control group and MDA content was significantly lower than that of the control group at 1 h and 2 h after the reperfusion. Conclusion:L-arginine has a protective effect in hepatic ischemia-reperfusion injury.