奥美沙坦对慢性心力衰竭患者胱抑素C水平的影响 |
| |
引用本文: | 康峰,易春,赖晓菁,梁希武. 奥美沙坦对慢性心力衰竭患者胱抑素C水平的影响[J]. 中国心血管病研究杂志, 2013, 0(10): 826-829 |
| |
作者姓名: | 康峰 易春 赖晓菁 梁希武 |
| |
作者单位: | 广州市荔湾区人民医院心内科,广东省510370 |
| |
摘 要: | 目的 观察慢性心力衰竭(CHF)患者血清胱抑素C(Cys C)的浓度变化,探讨奥美沙坦对CHF胱抑素C水平的影响.方法 血清Cys C浓度采用颗粒增强免疫比浊法测定.选取124例CHF患者,分为奥美沙坦组和依那普利组,奥美沙坦组64例,依那普利组60例.慢性心力衰竭依NYHA心功能分级标准,分为Ⅰ~Ⅳ级各亚组,测定各亚组在治疗前后血清Cys C浓度及血肌酐(Scr)浓度,并进行统计学分析.结果 两组患者Cys C浓度随NYHA分级增高而升高;Ⅱ~Ⅳ级分别与Ⅰ级相比,差别有统计学意义(P<0.05).Scr浓度从Ⅰ~Ⅳ级逐渐升高;NYHA Ⅰ~Ⅱ级Scr浓度升高不明显,两者差异无统计学意义(P>0.05);Ⅲ~Ⅳ级分别与Ⅰ级相比,血Scr浓度差异有统计学意义(P<0.05).NYHAⅠ~Ⅱ级亚组、Ⅱ~Ⅲ级亚组及Ⅲ~Ⅳ级亚组之间血清Cys C浓度差异有统计学意义(P<0.01).CHF患者血清Cys C的改变较Scr的改变出现迅速.治疗后,奥美沙坦组及依那普利组Cys C浓度均呈下降趋势(P<0.01),但奥美沙坦降低血清Cys C的作用更明显(P<0.05).结论 奥美沙坦能使CHF患者Cys C明显下降,可对肾功能起有效保护作用.
|
关 键 词: | 奥美沙坦 心力衰竭,充血性 胱抑素C |
The influence of olmesartan on the levels of serum cystatin C in patients with chronic heart failure |
| |
Affiliation: | KANG Feng, YI Chun,LAl Xiao-jing,et oi. Department of Cardiology, the People's Hospital of Liwan District, Guanhou 510370, China |
| |
Abstract: | Objective To observe changes of serum concentration of cystatin C (Cys C) in patients with chronic heart failure(CHF), and explore the influence of olmesartan on the levels of serum Cys C in CHF. Methods Particle enhanced immunoturbidimetry was used to detect serum Cys C concentration. We recruited 124 CHF pa- tients, which were further divided into olmesartan group(64 cases) and enalapril group(60 cases). According to NY- HA cardiac function classification criteria,CHF was divided into class I , l], m and IV. Serum Cys C concentration and serum creatine (Scr) concentration of each class were measured and analyzed before and after treatment. Results The Cys C concentration of two groups increased with NYHA cardiac function classification.Comparing with NYHA class I (1.31~0.16 mg/L),the Cys C level was significantly increased(P〈0.05)in NYHA class II (1.52~ 0.11 rag/L), 11[ (1.75 ~0.15 rag/L) and 1V (1.90~0.13 rag/L). Scr concentration of two groups were also increased with NYHA cardiac function classification,but it had no significant change in NYHA class I and II (93.92~13.41 vs 96.32~8.99, P〉0.05).In comparision with that of NYHA class I (93.92~13.41 p, mol/L), the Scr level was signifi- cantly increased(P〈0.05 )in NYHA class Ill (107.98~10.02 ~mol/L) and IV(111.74~12.41 p, mol/L). Serum Cys C concentration had significant change in NYHA class I and H (P〈0.01), NYHA class ]I and Iil (P〈0.01)and NY- HA class Ill and IV (P〈0.01). Changes of serum concentration of Cys C were more rapid than that of Scr in pa- tients with CHF. Although the levels of Cys C had decreased in two groups after treatment (P〈0.01), olmesartangroup should be more obvious (P〈0.05). Conclusion Olmesartan descendes serum Cys C concentration obvi- ouslyand would provide with more protection on renal function in patients with CHF. |
| |
Keywords: | Olmesartan Heart failure,congestive Cystatin C |
本文献已被 维普 等数据库收录! |
| 点击此处可从《中国心血管病研究杂志》浏览原始摘要信息 |
|
点击此处可从《中国心血管病研究杂志》下载免费的PDF全文 |
|