Bioactive lipids and their receptors |
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Authors: | Angel Itzchak Bar Adina Haring Rachel |
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Affiliation: | D-Pharm Ltd, Kiryat Weizmann Science Park, PO Box 2313, Rehovot 76123, Israel. iangel@dpharm.com |
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Abstract: | Recent studies show that several, if not all, degradative products of glycerol- and sphingosine-based lipids are active molecules that play important roles in different signal transduction pathways. The functions and actions of lysophosphatidic acid and sphingosine 1-phosphate, the degradation products of phospholipids and sphingolipids, respectively, have received a great deal of attention during the past few years. These lipid mediators are active through several abundant G protein-coupled receptors that were recently identified and characterized. This review will discuss recent achievements in the area of bioactive lipids. |
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