P物质及组胺受体拮抗剂对分泌性中耳炎中耳积液的影响

采用免疫组化ＡＢＣ－ＧＤＮ及图象分析技术研究分泌性中耳炎中耳粘膜Ｐ物质含量的变化与中耳积液的关系，并观察ＳＰ受体拮抗剂ｓｐａｎｔｉｄｅ及组胺Ｈ２受体阻滞剂ｃｉｍｅ－ｔｉｄｉｎ对ＭＥＥ的影响，探讨ＳＰ在ＳＯＭ中的作用。结果发现，在ＳＯＭ条件下，中耳粘膜ＳＰ含量有逐渐增多趋势，并和ＭＥＥ量呈正相关。

The effect of substance P upon middle ear effusion of secretory otitis media and the mode of action

This experiment aimed to explore the effects of substance P(SP) on secretory oti-tis media (SOM ). Both immunohistochemistry ABC-GDN and image pattern analysis techniquewere adopted to investigate the relation between SP content of SOM middle ear mucosa and middleear effusion,and observe the effect of SP receptor antagonist spantide and histamine H2 receptorblocker cimetidin on middle ear effusion. The findings showed:middle ear mucosa SP content tend-ed to increase, and had positive correlation with middle ear effusion, intra-abdominally injecting1mg/ml Spantide and 1mg/ml Cinetidin per day could have middle ear effusion decreased obvious-ly,but the quantities of reduction were more significant- The results suggest that SP plays a role inSOM, might accelerate vasodilation and increase the permeability of cupillary in middle ear mucosamediated by histamine.