| 4—[（4—氯苯基）（5—氟—2—羟基苯基）亚甲氨基]丁酰胺的质谱研究 |
| |
| 引用本文： | 袁牧,钟裕国.4—[（4—氯苯基）（5—氟—2—羟基苯基）亚甲氨基]丁酰胺的质谱研究[J].贵阳医学院学报,1993,18(1):15-19. |
| |
| 作者姓名： | 袁牧 钟裕国 |
| |
| 作者单位： | 贵阳医学院药物化学教研室，华西医科大学药学院，华西医科大学药学院，华西医科大学药学院 |
| |
| 摘 要： |
|
| 关 键 词： | γ氨基丁酸 分析 抗惊厥药 质谱 |
Study on the Mass Spectra of 4-[(4-Chlorophenyl)(5-Fluoro-2-Hydroxyphenyl) Methylene Amino] Butanamide |
| |
| Yuan Mu,et al.Study on the Mass Spectra of 4-[(4-Chlorophenyl)(5-Fluoro-2-Hydroxyphenyl) Methylene Amino] Butanamide[J].Journal of Guiyang Medical College,1993,18(1):15-19. |
| |
| Authors: | Yuan Mu |
| |
| Institution: | Yuan Mu,et al Department of Pharmaceutical Chemistry |
| |
| Abstract: | Progabide, 4-(4-chlorophenyl) (5-fluro-2-hydroxyphenyl) niethylene amino) butanamide, is a lipophilic compound that crosses the blood-brain barrier and possesses low toxicity. It is the first specific Y-aminobutyric acid (GABA) receptor agonist which has been undergone extensive clinical trials on epilepsy therapeutics. We have synthesized 4- (4-chorophenyl) (5-fluoro-2-hydroxyphenyl) methylene amino] bubanamide. The mass spectra of 4- (4-chlorophenyl) (5-fluoro-2-hydroxyphenyl) methylene amino) butanamide was reported and discussed. All the mass spectral fragmentations characteristics of 4-(4-chlorophenyl) (5-fluoro-2-hydroxyphenyl) methylene amino) butanamide were assigned. It shows that the results are consistent with the chemical structure. |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 等数据库收录！ |
