| 有机酸尿症的气相色谱—质谱联用初步研究(附49例正常儿尿有机酸的分析报告) |
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| 引用本文： | 赵世萍,林平,姜永,李其,李玉芬,徐力. 有机酸尿症的气相色谱—质谱联用初步研究(附49例正常儿尿有机酸的分析报告)[J]. 中日友好医院学报, 1988, 0(4) |
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| 作者姓名： | 赵世萍 林平 姜永 李其 李玉芬 徐力 |
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| 作者单位： | 中日友好医院临床医学研究所药物药理室，中日友好医院临床医学研究所药物药理室，中国医学科学院药物研究所，中日友好医院儿科，中日友好医院儿科，中日友好医院儿科 博士研究生 |
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| 摘 要： | 本文采用气相色谱法对49例正常儿的尿有机酸进行了分析,首次提出了我国正常儿尿有机酸成分的OV-17填充柱气相色谱谱图。并做了GC-MS联用分析,鉴定了乳酸、尿素、乙基丙二酸、丁二酸、延胡索酸、对羟基苯乙酸、对羟基苯乳酸等成份。同时对4例苯丙酮尿症患儿尿也进行了GC-MS联用分析,主要异常峰鉴定为苯丙酮酸及苯乳酸。
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| 关 键 词： | 尿有机酸 气相色谱谱图 气相色谱—质谱联用 |
PRELIMINARY STUDY ON AMINO ACID METABOLIC DISORDERS WITH ORGANIC ACIDURIAS BY GAS-CHROMATOGRAPHY AND MASS SPECTROMETRY |
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| Zhao Shiping,et al. PRELIMINARY STUDY ON AMINO ACID METABOLIC DISORDERS WITH ORGANIC ACIDURIAS BY GAS-CHROMATOGRAPHY AND MASS SPECTROMETRY[J]. Journal of China-Japan Friendship Hospital, 1988, 0(4) |
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| Authors: | Zhao Shiping et al |
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| Abstract: | This paper reports the Gas chromatographic map of 49 normal Chinese children's urinary organic acids on OV-17 column. The main peaks were identified as lactic acid, urea, ethylmalonic caid, succinic acid, fumaric acid, p-hydroxyphenyl acetic acid and p-hydroxyphenyllactic acid by GC-MS. We also analysed the urinary organic acids from four patients with phenylketonuria by GC-MS. The main abnormal peaks were identified as phenylpyruvic acid and phenyllactic acid. |
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| Keywords: | urinary organic acid gas-chromatography and mass-spectrometry gas chromatogram map |
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