The Y chromosome in forensic analysis and paternity testing |
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Authors: | M A Jobling A Pandya C Tyler-Smith |
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Institution: | (1) Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK FAX: +44 (116) 252 3378 e-mail: maj4@leicester.ac.uk, GB;(2) CRC Chromosome Molecular Biology Group, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK FAX: +44 (1865) 275 283 e-mail: chris@bioch.ox.ac.uk, GB |
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Abstract: | The male specificity of the human Y chromosome makes it potentially useful in forensic studies and paternity testing, and
markers are now available which will allow its usefulness to be assessed in practice. However, while it can be used confidently
for exclusions, the unusual properties of the Y mean that inclusions will be very difficult to make: haplotypes are confined
within lineages, so population sub-structuring is a major problem, and many male relatives of a suspect will share his Y chromosome.
Y haplotyping is most likely to find application in special instances, such as deficiency cases in paternity testing and in
the analysis of mixtures of male and female DNA, or in combination with autosomal markers.
Received: 31 December 1996 / Received in revised form: 4 March 1997 |
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Keywords: | Y chromosome Polymorphism Haplotype Exclusion Paternity testing |
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