外周血端粒酶的活性与高血压病

目的：探讨高血压病患外周血单个核细胞的端粒酶活性。方法：用端粒酶ＰＣＲ－ＥＬＩＳＡ方法测定９０例高血压病患与５６例血压正常外击血端粒酶的活性。结果：高血压组外周血单个核细胞的端粒酶活性比对照组明显增高（分别为５７％和２３％，Ｐ〈０．０００１），经多因素Ｌｏｇｉｓｔｃ回归分析，显示影响血压的主要因素是年龄、体重指数、血胰岛素水平和端粒酶；与端粒酶高表达有关的主要因素是高血压和淋巴细胞数，进一步

Telomerase Activity of Peripheral Blood Cells and Essentail Hypertension

Objective: To investigate die telomerase activity of peripheral blood mononuclear cells from patients with essentail hypertension. Methods: The telomerase activity of peripheral blood mononuclear cells in 90 hypertensives and 56 normotensives was measured widi Telomerase - PCR - ELISA assay. Results; The telomerase activity of peripheral blood mononuclear cells in hypertensive group was signifjcandy increased than dial in control group (57% and 23%, respectively, P < 0. 000 1) . Logistic Regression showed that the main influenced factors of hypertension were age, body mass index, blood insulin and telomerase activity, while the main influenced factors of the telomerase activity were hypertension and the number of lymphocyte. Further study showed that there had been increased telomerase activity in one - class and low - risk hypertensives, and it had not been increased with raised blood pressure and prognostic risk factors, Bui the telomerase activity was decreased with regular antihypertensive treatment. Conclution; The upregulation of telomerase activity in peripheral blood mononuclear cells might be one of risk factors in essentail hypertension.