宇宙飞行对航天员免疫系统的影响

目的概述近年来有关宇宙飞行影响航天员免疫系统功能的研究进展。资料来源与选择国内外相关文献35篇。资料综合论述了宇宙飞行对航天员免疫系统功能的影响及其可能机制。结论宇宙飞行可影响航天员免疫系统功能，导致细胞免疫功能减低，但是，体液免疫功能变化不明显。目前，对于宇宙飞行导致航天员免疫系统功能改变的可能机制，主要集中于太空复合因素以及由其引起的神经一内分泌系统改变对免疫系统的直接和间接影响。由于太空实验的数量有限且重复性差，所以，目前的研究结论都是初步性的，对于宇宙飞行对航天员免疫系统的确切影响还有待进一步研究。

Effects of spaceflight on function of immune system in astronauts

Objective To summarize the works of effects of space environments on function of immune system in astronauts. Literature resource and selection The related published articles in this field home and abroad. Literature quotation Thirty-five references were cited. Literature synthesis Influences of space environments on immune function of astronauts and its mechanisms were summarized and discussed. Conclusions Spaceflight might affect the immune function of cosmonauts and lower the cell immune response, however, it had little influence on humoral immune response. For the moment, most investigations suggest that the mechanism of changes of immune function is mainly related to space environments and variations of neuroendocrine system induced by space factors. At present, the times of space experiments are limited and its repeatability is low, so the conclusions are preliminary and further investigations are needed.