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| 血管性认知障碍患者血清脑源性神经营养因子水平的变化及其临床意义 | |
| 引用本文： | 王冬欣,张国芬,曹翠芳,张宁,张国华,张志涛.血管性认知障碍患者血清脑源性神经营养因子水平的变化及其临床意义[J].临床神经病学杂志,2010,23(1). |
| 作者姓名： | 王冬欣 张国芬 曹翠芳 张宁 张国华 张志涛 |
| 作者单位： | 1. 河北医科大学第二医院神经内科,石家庄,050000 2. 河北省藁城市人民医院 3. 河北医科大学临床学院 |
| 基金项目： | 河北省科学技术研究与发展计划项目(07276101D-82) |
| 摘 要： | 目的 探讨血管性认知障碍(VCI)患者血清脑源性神经营养因子(BDNF)水平的变化及其临床意义.方法 采用酶联免疫吸附法(ELISA)对42例VCI患者(其中轻度认知障碍20例,中度14例,重度8例)、49例同期非认知障碍脑梗死(NDCI)患者、46例同期正常体检者(NC)的血清BDNF水平进行测定并分析.结果 血清BDNF浓度呈非正态分布,VCI组血清BDNF得分均数(32.369)低于NDCI组(48.026),差异有统计学意义(P＜0.05);VCI组血清BDNF水平得分均数虽低于NC组(45.688),但差异无统计学意义.VCI组中,轻度、中度及重度认知障碍患者血清BDNF得分比较差异无统计学意义;在VCI组、NDCI组及NC组中,未发现血清BDNF水平与性别、年龄、体质量指数、文化程度、简易精神状态检查量表评分存在相关性.结论 VCI患者血清BDNF水平明显低于NDCI患者,提示BDNF可能参与了脑梗死进展为认知障碍的病理生理过程,但并不能反映认知障碍的严重程度. |
| 关 键 词： | 脑血管病 血管性认知障碍 脑源性神经营养因子 酶联免疫吸附法 |
Change and its clinical significance of serum levels of brain-derived neurotrophic factor in patients with vascular cognitive impairment |
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| WANG Dong-xin,ZHANG Guo-fen,CAO Cui-fang,et al.Change and its clinical significance of serum levels of brain-derived neurotrophic factor in patients with vascular cognitive impairment[J].Journal of Clinical Neurology,2010,23(1). | |
| Authors: | WANG Dong-xin ZHANG Guo-fen CAO Cui-fang |
| Institution: | WANG Dong-xin,ZHANG Guo-fen,CAO Cui-fang,et al.Department of Neurology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China |
| Abstract: | Objective To investigate the change and its clinical significance of serum levels of brain-derived neurotrophic factor(BDNF)in patients with vascular cognitive impairment(VCI).Methods The serum levels of BDNF in 42 VCI patients(20 cases of mild VCI,14 cases of moderate VCI and 8 cases of severity VCI),49 cerebral infarction patients without dementia(NDCI)and 46 normal controls were measured by enzyme-linked immunosorbant assay(ELISA),and the results were analyzed.Results The serum levels of BDNF were nonnor... |
| Keywords: | cerebral vascular disease vascular cognitive impairment brain-derived neurotrophic factor enzyme-linked immunosorbant assay |
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