Exercise-induced alterations in natural killer cell number and function |
| |
Authors: | Niall M. Moyna Gwendolyn R. Acker Kelly M. Weber Jonathan R. Fulton Robert J. Robertson Fredric L. Goss Bruce S. Rabin |
| |
Affiliation: | (1) Department of Pathology, Division of Immunopathology, University of Pittsburgh Medical Center, 200 Lothrop St, 15213-2582 Pittsburgh, PA, USA;(2) Human Energy Research Laboratory, University of Pittsburgh, University of Pittsburgh, 242 Trees Hall, 15261 Pittsburgh, PA, USA |
| |
Abstract: | To study the effects of exercise on natural killer (NK) cell number and activity (NKCA) healthy male (n = 32) and female (n = 32) subjects were randomly assigned to an exercise or control condition. Exercise involved a continuous incremental protocol consisting of cycling for three periods of 6 min at work rates corresponding to 55%, 70% and 85% peak oxygen uptake ( ). Blood samples were drawn at baseline, at 6 min, 12 min and 18 min during exercise, and at 2 h following completion of exercise. Relative to both baseline and control conditions, exercise resulted in an increase in the number of circulating lymphocytes. The proportion of T cells (CD3+) and B cells (CD19 +) significantly decreased, and NK cells (CD3–CD16+CD56+) increased throughout exercise. NKCA increased (P < 0.001) during the initial 6 min of exercise with no further changes observed, despite increases (P < 0.001) in the number and proportion of circulating NK cells during exercise at 70% and 85% . Plasma epinephrine and norepinephrine increased (P < 0.001) above baseline at 12 min and 18 min. The changes in NK cell number and function were independent of gender. The results indicate that short-duration low-intensity exercise can significantly increase NK cell number and activity. However, alterations in NK cell number are not accompanied by changes of a similar magnitude in NKCA. |
| |
Keywords: | Exercise Natural killer cells Gender Immune function |
本文献已被 SpringerLink 等数据库收录! |
|