颈动脉支架置入术对无症状重度颈动脉狭窄患者认知功能的影响

目的探讨颈动脉支架置入术（carotid artery stenosis，CAS）对无症状重度颈动脉狭窄患者认知功能的影响。方法纳入行CAS的无症状重度颈动脉狭窄（狭窄程度≥70％）患者，分别于CAS术前、术后1个月和3个月采用简易智能状态检测量表（Mini-Mental Status Examination，MMSE）、数字广度测验（Digital Span，DS）、中文听觉词汇学习测验（Chinese Auditory Learning Test，CALT）、线段方向判定测验（Judgment of Line Orientation Test，JLOT）和语言流畅性测验（Verbal Fluency Test，vFT）进行认知功能评价，包括注意、记忆、视空间以及额叶流畅性功能。结果共纳入26例行CAS的无症状重度颈动脉狭窄患者患者，男性18例，女性8例，年龄52～79岁，平均（64．19±6．76）岁，受教育年限（9．84±3．29）年；左侧颈动脉狭窄18例，右侧颈动脉狭窄8例；均成功行CAS，未发生并发症。与CAS术前比较，术后1个月和3个月时各项认知功能均显著性改善（P均〈0．01），但术后1个月与3个月时无显著性差异（P均〉0．05）。结论CAS能改变无症状重度颈动脉狭窄患者的认知功能，术后早期较为明显。

Effect of carotid artery stenfing on cognitive function in patients with asymptomatic severe carotid artery stenosis

Objective To investigate the effect of carotid artery stenting （CAS） on cognitive function in patients with asymptomatic severe carotid artery stenosis. Methods The patients with asymptomatic severe carotid stenosis （stenosis ≥ 70%） were enrolled in the study. The cognitive function evaluation was performed before CAS, 1 and 3 months after procedure respectively with mini-mental status scale （MMSE）, digital span （DS）, Chinese auditory learning test （CALT）, judgment of line orientation test （JLOT）, and verbal fluency test （VFT）, including attention, memory, visual spatial function, and frontal fluency function. Results A total of 26 patients with asymptomatie severe carotid artery stenosis who performed CAS were enrolled, 18 were males and 8 were females （aged 52 to 79 years, mean 64. 19±6. 76 years）, and the years of education was 9.84 ± 3.29 years. Eighteen patients had left carotid artery stenosis and 8 had contralateral carotid artery stenosis. CAS was performed successfully in all patients, and no complications occurred. Compared with the CAS before procedure, all the cognitive functions were improved significantly at 1 and 3 months after procedure （all P 〈0. 01）, however, there was no significant difference between 1 and 3 months after procedure （all P〉 0. 05）. Conclusions CAS may improve cognitive function in patients with asymptomatic severe carotid artery stenosis, and it was more obvious in the early postoperative period.