不同类型冠心病患者血清炎症因子的水平对比

目的了解不同类型冠心病患者血清炎症因子的水平,探讨炎症因子在冠心病发生、发展中的作用及临床意义。方法检测急性心肌梗死组(AMI)、不稳定型心绞痛组(UAP)、稳定型心绞痛组(SAP)、无冠心病者(对照组)的血清高敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)、可溶性白细胞分化抗原40配体(sCD40L)的水平并进行统计学比较。结果与对照组比较,AMI、UAP组的血清炎症因子的水平均明显增高(P<0.05);与SAP组比较,AMI、UAP组的血清炎症因子的水平均明显增高(P<0.05);与UAP组比较,AMI组的血清炎症因子的水平均明显增高(P<0.05)。结论 hs-CRP、MMP-9、sCD40L均参与了冠状动脉粥样硬化的发生与发展,而且这些血清炎症因子的水平高低与冠心病的严重程度相关。

A comparative study on serum levels of inflammatory factors in patients with different types of coronary heart diseases

Objective To compare serum levels of inflammatory factors in patients with different types of coronary heart diseases, and to study the role of inflammatory factors in development of coronary heart diseases. Methods Serum levels of high - sensitivity C - reactive protein, matrix metalloproteinase-9 （MMP- 9 ）, soluble CD40 ligand in patients with acute myocardial infarction （AMI）, unstable angina pectoris （UAP）, stable angina pectoris（SAP） and control group（CG） were determined and statistically analyzed. Results Serum levels of inflammatory factors in patients with AMI and UAP were obviously higher than those of patients in SAP group and control group （ P 〈 0.05 ）. Serum levels of inflammatory factors in patients with AMI were obviously higher than those of patients with UAP（ P 〈 0.05 ）. Conclusion Serum levels of Hs - CRP, MMP -9 and sCD40L are all participated in the development of coronary heart diseases, and serum levels of inflammatory factors are correla- ted with the severity of coronary heart diseases.