医院MRSA感染危险因素分析

目的分析医院耐甲氧西林金黄色葡萄球菌(MRSA)感染危险的因素,以便采取有效措施降低感染率。方法对各科室送检标本实施MRSA菌株分离,然后采用1∶1成组病例对照选取非医院MRSA感染患者60例,并与60例医院MRSA感染患者料进行单因素分析、多因素研究分析。结果单因素分析结果显示高龄、住院时间长、抗生素使用超过2种、广谱抗菌药使用时间超过7 d、侵入性操作超过2项等因素与医院MRSA感染有关。多因素分析结果显示医院MRSA感染的危险因素主要有住院时间长、侵入性操作超过2项、广谱抗菌药使用时间超过7 d和抗生素使用超过2种。结论侵入性操作、长时间住院、光谱抗菌药长时间使用和抗菌药的不合理应用是医院MRSA感染的危险因素。

Risk factors of nosocomial MRSA infection

Objective To analyze the risk factors of nosocomial meticillin-resistant Staphylococcus aureus（MRSA） infections,so as to take effective measures to reduce nosocomial MRSA infection rates.Methods MRSA isolates were isolated from specimens collected from departments of the hospital.The data of the patients including 60 cases of MRSA infection from the hospital and 60 cases of MRSA infection from outside the hospital were analyzed by single factor analysis and multiple factors analysis.Results According to the single factor analysis,old age,long stay in hospital,more than 2 kinds of antibiotics used,broad-spectrum antibiotics used more than 7 days,and more than 2 invasive procedures performed were related to nosocomial MRSA infection.Multiple factors analysis showed that the risk factors of nosocomial MRSA infection were long stay in hospital,more than 2 kinds of antibiotics used,broad-spectrum antibiotics used more than 7 days,and more than 2 invasive procedures performed.Conclusion The risk factors of nosocomial MRSA infection involve invasive procedures,long stay in hospital,long time use of broad-spectrum antibiotics and irrational use of antibiotics.