血浆置换治疗慢性重型肝炎的疗效研究

目的 探讨血浆置换(PE)治疗慢性重型肝炎的疗效.方法 将70例慢性重型肝炎住院患者随机分为PE组和对照组,PE组在内科综合治疗基础上联合PE,对照组仅给予内科综合治疗,疗程为1个月.结果 PE组在TBil、ALT、CHO、CHE、PTA、BUN及Cr方面改善明显优于对照组(P<0.05);PE组总有效率为62.86%,对照组为31.43%,PE组明显高于对照组(P<0.05);住院期间内PE组死亡率为11.42%,而对照组高达31.42%,两者比较差异有统计学意义(P<0.05).结论 PE联合内科综合治疗可以明显提高慢性重型肝炎的治疗效果,是一种安全可靠的治疗方法.

Study on effect of plasma exchange in treating chronic severe hepatitis

Objective To investigate the effect of plasma exchange (PE) in the treatment of chronic severe hepatitis. Methods 70 cases with chronic severe hepatitis were divided randomly into two groups:treatment group and control group. The treatment group combined with PE based on combined therapy of internal medicine, control group was only performed combined therapy of internal medicine. The therapeutic efficient rate was analyzed by con-trast after one month. Results The level of TBil,ALT,CHO,CHE,PTA,BUN and Cr of patients in treatment group improved more obviously than those in control group(P <0.05). The total effective rate was 62.86% in treatment group and was 31.43% in control group,and there were significant differences in two groups(P <0.05). The death rate was 11.42% in treatment group and was 31.42% in control group,there were significant differences in two groups (P < 0.05). Conclusion PE combined with therapy of internal medicine can obviously improve therapeutic efficient rate of chronic severe hepatitis,which is an safe and effective method.