| Duchenne型肌营养不良症的冷冻断裂电镜观察 |
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| 引用本文： | 慕容慎行,吴翊钦.Duchenne型肌营养不良症的冷冻断裂电镜观察[J].中国临床神经科学,1994,2(4):212-214. |
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| 作者姓名： | 慕容慎行 吴翊钦 |
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| 作者单位： | 福建医学院附属第一医院神经内科，福建医学院附属第一医院神经内科，福建医学院附属第一医院神经内科，福建医学院电子显微镜室，福建医学院电子显微镜室，福建医学院电子显微镜室 350005，350005，350005 |
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| 摘 要： | 应用冷冻断裂电镜技术对Duchenne型肌营养不良症(DMD)的骨胳肌标本4例(异常组),正常标本2例(正常组)肌细胞质膜的蛋白颗粒进行电镜观察。结果表明,正常组和异常组的EF(extracellular face)面膜蛋白颗粒比PF(protoplasmic face)面少;异常组与正常组比较,其EF面和PF面的膜蛋白颗粒均明显减少,并具有显著的统计学意义。
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| 关 键 词： | 冷冻断裂 电子显微镜术 质膜 Duchenne型肌营养不良症 |
Freeze-fracture Electron Microscopic Observation on Muscle Plasma Membrane of Duchenne Muscular Dystrophy |
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| Murong Shen-Xing,Yao Yi-Qing,Wang Ning
Wu Yl-Qin,Liang Pi,Zhong Yu-Rong.Freeze-fracture Electron Microscopic Observation on Muscle Plasma Membrane of Duchenne Muscular Dystrophy[J].Chinese Journal of Clinical Neurosciences,1994,2(4):212-214. |
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| Authors: | Murong Shen-Xing Yao Yi-Qing Wang Ning
Wu Yl-Qin Liang Pi Zhong Yu-Rong |
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| Institution: | Murong Shen-Xing,Yao Yi-Qing,Wang Ning
Wu Yl-Qin,Liang Pi,Zhong Yu-Rong Department of Neurology,Fujian Medical College |
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| Abstract: | Intramembrane proteinic particles of muscle plasma membrane were calculated with freeze-fracture electron microscopy in 4 cases of Duchenne muscle dystrophy (DMD) . The result shows that intramembrane proteinic particles of extracellular face (EF) are fewer than those of protoplasmic face (PF) in DMD and normal control, and intramembrane particles of both EF and PF are diminished in DMD as compared with those of normal control. The difference is statistically significant. |
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| Keywords: | Freeze-fracture Electron microscopy Plasma membrane Duchenne muscular dystrophy |
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