血栓调节蛋白水平与冠心病关系的研究

目的：探讨血栓调节蛋白水平(Thrombomdulin,TM)与冠心病(coronary heart disease,CHD)的相关性。方法：81例CHD者(CHD组)均在我院确诊;57例健康体检者为对照组;均采用酶联免疫吸附法(ELISA)方法,检测外周血浆TM水平;比较两组TM水平差异;多元线性回归分析冠心病危险因素对TM的影响;Pearson相关分析TM水平与动脉硬化指数的关系;受试者工作特征曲线(ROC曲线)分析TM对CHD诊断价值。结果：CHD组TM水平明显高于对照组(P<0.05)。TM水平与动脉硬化指数存在正相关(P<0.056);ROC曲线下面积为0.596,面积的95%CI：0.498～0.694,TM判断CHD无显著意义(P=0.056)。结论：CHD患者TM水平明显升高;但TM判断CHD无显著意义。

Study on association between Thrombomdulin measured by ELISAand coronary heart disease

Objective To investigate the relationship between Thrombomdulin (TM) and coronary heart disease (CHD). Methods: 81 patients with CHD (CHD group) were diagnosed in our hospital, 57 cases of healthy physical examination as the control group. The TM level was detected by enzyme-linked immunosorbent assay (ELISA). Comparison of TM levels in the two groups.Multiple linear regression analysis the effect of risk factors of coronary heart disease on TM.Pearson correlation analysis the relationship between TM levels and arterial stiffness index. Analysis of the significance of TM in the diagnosis of CHD by receiver operating characteristic(ROC curve).Results: The level of TM in CHD group was significantly higher than that in control group (P<0.05). There was positively correlation between TM levels and arterial stiffness index (P<0.05).The area under the ROC curve was 0.596, and the area of 95%CI:0.498 ~ 0.694.TM has no significant value in judging CHD(P=0.056). Conclusion: The level of TM in patients with CHD was significantly increased, but it was not significantly value in the diagnosis of CHD.