| 空肠弯曲菌亚单位脂质体佐剂疫苗诱导抗体产生规律的研究 |
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| 引用本文： | 李成文,孙万邦,余妍,李官成,宋明英.空肠弯曲菌亚单位脂质体佐剂疫苗诱导抗体产生规律的研究[J].泸州医学院学报,2005,28(6):502-504. |
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| 作者姓名： | 李成文 孙万邦 余妍 李官成 宋明英 |
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| 作者单位： | 1. 泸州医学院免疫学教研室,四川泸州,646000
2. 遵义医学院珠海校区免疫教研室 |
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| 基金项目： | 贵州省社会发展重点课题 |
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| 摘 要： | 目的:探索空肠弯曲菌(campylobacter jejuni,CJ)亚单位脂质体佐剂疫苗诱导抗体产生的一般规律,为该疫苗的接种打下一定基础.方法:将CJ疫苗经肌肉注射免疫新西兰家兔后动态收集血清,以ELISA间接法测其特异性IgG OD值.结果:第一次免疫后10天左右,血清中即可检测到IgG,50天左右即达到高峰,此后逐渐降低,较高抗体水平可维持6个月左右.结论:CJ亚单位疫苗在1月内接种3次最佳,6个月后应该加强免疫.
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| 关 键 词： | 空肠弯曲菌 亚单位疫苗 抗体 规律 |
| 文章编号： | 1000-2669(2005)6-0502-03 |
| 收稿时间： | 04 30 2005 12:00AM |
| 修稿时间： | 2005年4月30日 |
STUDY ON REGULARITY OF ANTIBODY FORMATION INDUCED BY SUBUNIT VACCINE WITH LIPOSOMAL ADJUVANT FOR CAMPYLOBACTER JEJUNI |
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| Li Chengwen, et al.STUDY ON REGULARITY OF ANTIBODY FORMATION INDUCED BY SUBUNIT VACCINE WITH LIPOSOMAL ADJUVANT FOR CAMPYLOBACTER JEJUNI[J].Journal of Luzhou Medical College,2005,28(6):502-504. |
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| Authors: | Li Chengwen |
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| Institution: | Department of Immunology, Luzhou Medical College |
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| Abstract: | Objective: To explore the regularity of antibody formation induced by Subunit Vaccine with Liposomal Adjuvant for CJ and to establish a foundation for vaccination of the CJ vaccine. Methods: Serums of New Zealand rabbits were successively collected which were vaccinated with the CJ vaccine. The levels of the special IgG in the serum were detected by indirect ELISA. Results: The special IgG in the serum could be detected ten days after the first vauination. The level of IgG reached its peak at the fiftieth day and then dropped gradually. The relatively high level could be maintained for six months or so. Conclusion: The subunit vaccine of CJ should be vaccinated three times in the first month and strengthened after six months. |
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| Keywords: | Campylobacter jejuni Subunit vaccine Antibody Regularity |
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