In vivo metabolic action of insulin-like growth factor I in adult rats |
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Authors: | F. Schmitz Dr. H. Hartmann F. Stümpel W. Creutzfeldt |
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Affiliation: | (1) Division of Gastroenterology and Endocrinology, Department of Medicine, University of Göttingen, Göttingen, FRG;(2) Medizinische Universitätsklinik, Robert-Koch-Strasse 40, W-3400 Goettingen, FRG |
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Abstract: | Summary The acute metabolic actions of insulin-like growth factor I were studied in anaesthetized adult rats and its potency was compared to that of insulin. Following an i. v. bolus injection of insulin-like growth factor I a dose-dependent decrease of blood glucose and serum non-esterified fatty acid concentrations was noted with a potency of about 2% that of insulin. Stimulation of total body glucose disposal during euglycaemic clamping required 50times higher insulin-like growth factor I serum concentrations to achieve an identical half-maximal response. A similar difference in potency was observed for the stimulatory action on 2-de-oxyglucose uptake and on glycogen formation in skeletal muscle. Lipogenesis in epididymal fat pads was increased dose-dependently by both hormones requiring approximately 30 times higher half-maximally effective serum concentrations of insulin-like growth factor I. These data demonstrate that insulin-like growth factor I exerted acute insulin-like metabolic actions in vivo with low potency. These effects were probably mediated via insulin receptors. A preferential stimulation of glucose metabolism in skeletal muscle was not observed. |
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Keywords: | Insulin insulin-like growth factor I euglycaemic clamping glucose metabolism lipogenesis glycogenesis |
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