| 睾丸素母液中两个新差向异构体的分离与结构鉴定睾丸素母液中两个新差向异构体的分离与结构鉴定 |
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| 引用本文： | 杨中铎,王友富,林力波,李援朝.睾丸素母液中两个新差向异构体的分离与结构鉴定睾丸素母液中两个新差向异构体的分离与结构鉴定[J].药学学报,2004,39(7):528-530. |
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| 作者姓名： | 杨中铎 王友富 林力波 李援朝 |
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| 作者单位： | 1. 中国科学院,上海生命科学院药物研究所,上海,201203
2. 浙江仙居制药二分厂 |
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| 摘 要： | 目的研究药物睾丸素中所含的杂质。方法应用柱色谱方法进行分离和纯化，NMR和MS等波谱解析化学结构。结果从睾丸素母液中分离得到2个化合物。结论化合物1,2为新差向异构体，其结构分别鉴定为：3α-乙氧基雄甾-4-烯-17β-醇(1),3β-乙氧基雄甾-4-烯-17β-醇(2)。
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| 关 键 词： | 睾丸素 3α-乙氧基雄甾-4-烯-17β-醇 3β-乙氧基雄甾-4-烯-17β-醇 |
| 收稿时间： | 2003-08-31 |
The isolation and identification of two new epimer from the mother liquid of testosterone |
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| YANG Zhong-duo,WANG You-fu,LIN Li-bo,LI Yuan-chao.The isolation and identification of two new epimer from the mother liquid of testosterone[J].Acta Pharmaceutica Sinica,2004,39(7):528-530. |
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| Authors: | YANG Zhong-duo WANG You-fu LIN Li-bo LI Yuan-chao |
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| Institution: | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
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| Abstract: | AIM: To study the impurity of the drug testosterone. METHODS: Chromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis. RESULTS: Two new epimers were isolated from the mother liquid of the drug. CONCLUSION: These new epimers were identified as 3alpha-ethoxyandrost-4-en-17beta-ol, 3beta-ethoxyandrost-4-en-17beta-ol. |
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| Keywords: | 3α-ethoxyandrost-4-en-17β-ol 3β-ethoxyandrost-4-en-17β-ol testosterone |
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